id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-007796-zggk0x2q	Lindemans, Caroline A.	The Immune Response to Viral Lower Respiratory Tract Infection	2005		.txt	text/plain	9767	518	38	In respect to the role of viruses in the pathogenesis of acute and chronic airway disease in children, it is of utmost importance that we gain a proper understanding of the underlying mechanisms involved in order to design effective therapeutic and preventive strategies. Epithelial cells are key regulators of the innate immune response against viral infections (Garofalo and Haeberle, 2000) , producing a number of inflammatory mediators in response to RSV infection. In summary, in RSV lower respiratory tract infections, cytotoxic CD8ϩ T-cells are involved in viral clearance while the humoral response is required for the protection against reinfection. The innate immune defense to viral respiratory tract infections consists of the mucosal layer, type 1 interferons, activated phagocytes, and NK-cells. A key question is whether the association with the development of asthma is merely an expression of increased susceptibility to both asthma and RSV-induced lower respiratory tract infections or whether true causality is involved.	./cache/cord-007796-zggk0x2q.txt	./txt/cord-007796-zggk0x2q.txt