id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-009615-xcz8m9a7	Stoner, Gerald L.	Polyomavirus Models of Brain Infection and the Pathogenesis of Multiple Sclerosis	2008-01-28		.txt	text/plain	6395	329	44	Animal models of viral demyelination and studies showing that JC virus (JCV), the polyomavirus which causes progressive multifocal leukoencephalopathy (PML), may be latent in some normal human brains suggest another possibility. It is thought that an MS virus could be one of two basic types: 1) A rare agent which infects relatively few individuals but is frequently pathogenic, or 2) A common agent which infects a majority of the population and perhaps a significant number of normal brains, but, in which the virus expression and the host response to the infection ( Immunocytochemical studies in our laboratory indicate that perivascular cellular infiltration, apparently due to immunological reactivity to SV40 antigens, occurs in this model (Fig. 1) . Thus, simian immunodeficiency virus (S1V)-infected macaques should be observed regularly for the possible occurrence of MS-like signs with demyelination attributable to mononuclear cell infiltration in response to abortively infected glial cells, rather twa-stage process of deletion and duplication known as "brain adaptation" to generate the progressive multifocal leukoencephalopathy (PML)-type viral genome capable of replicating in glial cells of the human brain.	./cache/cord-009615-xcz8m9a7.txt	./txt/cord-009615-xcz8m9a7.txt