id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-009836-7o6htufh	Borrow, Persephone	Cytotoxic T‐lymphocyte escape viral variants: how important are they in viral evasion of immune clearance in vivo?	2006-04-28		.txt	text/plain	10041	299	34	Epitope mapping performed using the Gpl 60 sequence of the patient's autologous early HIV-1 population indicated that this response was in fact extremely focused on a single epitope encompassing Gpl60 amino acids 30-38(9), recognized in association with HLA-B44, The frequency of epitope-specific CTL was extremely high: at the earhest timepoint available for study, which may have been shghtly after the peak of the primary immune response, 1 in 1 7 peripheral blood mononuclear cells (EBMCs) were found to score as virus-specific CTL precursors by limiting dilution analysis, a technique which has recently been shown to greatly underestimate the total numher of epitope-specific T cells (55, 56) , As shown in Fig, 1 , viral variants bearing mutations in the epitopic sequence which conferred escape from recognition by epitope-specific CTL rapidly appeared in this patienc, and then increased in frequency until 164/1998 they had cotnpieteiy repiaced the transmitted virai strain.	./cache/cord-009836-7o6htufh.txt	./txt/cord-009836-7o6htufh.txt