id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-010222-5oxie0zc	Oldstone, Michael B.A.	Virus-induced autoimmunity: Molecular mimicry as a route to autoimmune disease	2004-04-11		.txt	text/plain	2752	125	39	Because the studies described above indicate that many viruses share antigenic determinants (linear or conformation) with normal host proteins, the next step was to determine experimentally whether molecular mimicry could elicit autoimmune diseases. The most likely explanation for how molecular mimicry causes disease is that an immune response against the determinant shared by host and virus takes the form of a tissue-specific attack, presumably capable of destroying cells and eventually the tissue. In any case, molecular mimicry would occur only when the virus and host determinants are sufficiently similar to induce a cross-reactive response yet different enough to break B or T-cell immunologic tolerance. Thus, the human AChR a-chain 160-167 peptide specifically cross-reacts with a shared homologous domain on herpes simplex virus glycoprotein D, residues 286-293, by binding and inhibition studies, and elicits antibodies in myasthenic patients that bind to the native AChR protein; these antibodies are capable of causing a biologic effect.	./cache/cord-010222-5oxie0zc.txt	./txt/cord-010222-5oxie0zc.txt