id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-011917-6u0t4hy8	Skarlupka, Amanda L.	Immune Imprinting in the Influenza Ferret Model	2020-04-08		.txt	text/plain	7904	456	37	Therefore, the use of naïve ferret sera for vaccine strain selection is potentially misrepresentative of the pre-immune human population that receives each season's influenza virus vaccines, contributing to the observed VE. Unique to sequentially infected ferrets, the elicited antibody profile was broader and interacted with pandemic A(H1N1) HA compared to the single pre-immunity groups as measured with HA-specific ELISA binding. In contrast to previous reports that pre-immunity induced protection does not wane [68] , the boosts in anti-HA stalk antibodies and the cross-reactivity induced from sequential infection with antigenically distinct seasonal A(H1N1) declined over time [74] . The current pre-immunity models are moving away from investigating the differences in disease symptoms and vaccine effectiveness observed in the human population in response to the pandemic virus. Pre-immunity to a historical A(H3N2) virus helped boost the magnitude and breadth of the broadly neutralizing antibodies elicited by computationally optimized broadly reactive antigen (COBRA) immunogens compared to a naïve ferret group [37] .	./cache/cord-011917-6u0t4hy8.txt	./txt/cord-011917-6u0t4hy8.txt