id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-012582-k1mjik27	Gallego, Iván	Stronger Together: Multivalent Phage Capsids Inhibit Virus Entry	2020-08-27		.txt	text/plain	1579	95	44	This report highlights a phage capsid scaffold strategy that can be used to precisely position sialic acid moieties to inhibit influenza A virus replication. This report highlights a phage capsid scaffold strategy that can be used to precisely position sialic acid moieties to inhibit influenza A virus replication. In this work, the authors have selected the icosahedral capsid of the bacteriophage Qβ as the rigid scaffold for the attachment of the sialic acid to achieve a structurally defined presentation of the ligands that matches the binding sites of the trimeric hemagglutinin. All these findings demonstrate that these phage capsid nanoparticles can be employed as efficient inhibitors of influenza A virus and may be the first step towards the development of a new group of antivirals based on protein scaffolds for the treatment of influenza. This new approach from the Hackenberger group represents a promising example of how controlled protein assemblies can be used as precise multivalent scaffolds in the development of innovative antiviral therapeutics.	./cache/cord-012582-k1mjik27.txt	./txt/cord-012582-k1mjik27.txt