id author title date pages extension mime words sentences flesch summary cache txt cord-016652-x8t3lf1x Matthews, David Viruses and the Nucleolus 2011-05-23 .txt text/plain 6630 348 33 This process is crucial for virus biology because if the viral proteins that are required for cytoplasmic functions such as RNA synthesis and encapsidation are sequestered in the nucleolus or nucleus, then progeny virus production will be affected as has been revealed by inhibitor and genetic studies (Lee et al. Viruses may interact with the nucleolus to usurp host cell functions and recruit nucleolar proteins to facilitate virus replication. Initial studies utilising the prototype g-2 herpesvirus, herpes virus saimiri (HVS), demonstrated that the HVS nucleolar trafficking ORF57 protein induces nucleolar redistribution of the host cell human TREX proteins, which are involved in mRNA nuclear export (Boyne and Whitehouse 2006) . The localisation of porcine reproductive and respiratory syndrome virus nucleocapsid protein to the nucleolus of infected cells and identification of a potential nucleolar localization signal sequence Sequence requirements for nucleolar localization of human T cell leukemia virus type I pX protein, which regulates viral RNA processing ./cache/cord-016652-x8t3lf1x.txt ./txt/cord-016652-x8t3lf1x.txt