id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-018165-afzjx2ci	Modrow, Susanne	Vaccines	2013-08-12		.txt	text/plain	4013	213	43	Live vaccines contain attenuated, replication-competent pathogens that can replicate in the vaccinated person, i.e. they are able to infect certain cells and initiate the synthesis of viral proteins and particles, but without triggering the respective clinical picture. Therefore, the immune response that is triggered by attenuated viruses is suitable to induce a long-lasting, effective protection against infections with the respective pathogen. Similarly, vaccinia viruses that were originally used to produce a protective immune response against smallpox virus induced local infections in humans, which in very rare cases had a generalized or fatal course. It is being attempted to modify well-explored, less pathogenic viruses (e.g. adenoviruses) and vaccine viruses that were used successfully in the past (usually vaccinia viruses) by using genetic engineering methods in such a way that they encode proteins of other viral species, in addition to their own gene products necessary for infection and replication (▶ Sects.	./cache/cord-018165-afzjx2ci.txt	./txt/cord-018165-afzjx2ci.txt