id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-018265-twp33bb6	Becker, Pablo D.	Community-acquired pneumonia: paving the way towards new vaccination concepts	2007		.txt	text/plain	14121	697	36	A live vaccine based on a master virus strain developed at the Institute of Applied Microbiology (Austria) by growing wild influenza virus in Vero cells at 25°C was also demonstrated to be safe, well-tolerated and immunogenic after intranasal immunization in young adults [18]. Candidate vaccines should be able to replicate and induce a protective immune response in young infants, even in the presence of maternally acquired antibodies. This demonstrates that antibodies play a major role in protection against this disease, whereas T-cell immunity targeted to internal viral proteins appears to contribute to clearance. The second generation of PS-based conjugate vaccines stimulates stronger antibody responses, even in infants, young children and immune deficient individuals, as well as immunological memory. The resulting proteins are then used to perform immunological and/or functional studies to select the most promising candidates (e.g., able to induce the production of microbicidal or neutralizing antibodies, capacity to confer protective immunity).	./cache/cord-018265-twp33bb6.txt	./txt/cord-018265-twp33bb6.txt