id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-018477-hgvqd1ej	Modrow, Susanne	Pathogenesis	2013-08-12		.txt	text/plain	3661	210	51	These cells are loaded with the virus particles and proteins and migrate to the immunologically active centres of the nearest lymph nodes, encountering there other immune cells such as CD4 + and CD8 + T lymphocytes, B lymphocytes and macrophages, which start to proliferate by contact with the pathogen proteins or with MHC-peptide complexes and by the influence of cytokines secreted by activated immune cells (▶ Chaps. During herpes simplex virus infections of the conjunctiva and the cornea, reactivated pathogens migrate from the ganglia of the nerve fibres into the eye, where they may spread in the epithelium of the cornea and cause inflammations. In pregnant women, haematogenously disseminated viruses such as rubella virus, cytomegalovirus and parvovirus B19 are transported via the bloodstream into the placenta and infect the endothelial cells of this organ. Other viruses, such poliovirus and tick-borne encephalitis virus, overcome the barriers probably by infection of endothelial cells, as occurs by infecting other organs (▶ Sects.	./cache/cord-018477-hgvqd1ej.txt	./txt/cord-018477-hgvqd1ej.txt