id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-022128-r8el8nqm	Domingo, Esteban	Molecular basis of genetic variation of viruses: error-prone replication	2019-11-08		.txt	text/plain	17663	798	39	In the case of viral genomes, mutations can result from different mechanisms: (i) template miscopying (direct incorporation of an incorrect nucleotide); (ii) primer-template misalignments that include miscoding followed by realignment, and misalignment of the template relative to the growing chain (polymerase "slippage" or "stuttering"); (iii) activity of cellular enzymes (i.e., deaminases), or (iv) chemical damage to the viral nucleic acids (deamination, depurination, depyrimidination, reactions with oxygen radicals, direct and indirect effects of ionizing radiation, photochemical reactions, etc.) (Naegeli, 1997; Bloomfield et al., 2000; Friedberg et al., 2006) . In addition to the general environmental and sequence context consequences for templatecopying fidelity that may affect any genome type, mutation rates for DNA viruses will also be influenced by: (i) whether the DNA polymerase that catalyzes viral DNA synthesis includes or lacks a functional proofreading-repair activity.	./cache/cord-022128-r8el8nqm.txt	./txt/cord-022128-r8el8nqm.txt