id author title date pages extension mime words sentences flesch summary cache txt cord-022324-tcltmhi7 Barthold, Stephen W. MOUSE HEPATITIS VIRUS BIOLOGY AND EPIZOOTIOLOGY 2012-12-02 .txt text/plain 5622 320 42 Interest in MHV has evolved from a number of different perspectives, including emphasis on MHV as a model of viral hepatitis, viral encephalitis and demyelinating disease, genetic mechanisms of host resistance to viral infection, and the molecular biology of coronaviruses, using MHV as a prototype. Virus strain, passage history, dose, route of inoculation, host genotype, age, immune function and co-infection with other agents all interact to determine the ultimate expression of MHV disease. Mice of the semisusceptible C3H genotype that survive intraperitoneal inoculation of virulent MHV-3 can have persistent infections, in which virus can be recovered in low titer from liver, brain and lymphoid organs for up to 42 days (68). Therefore, when MHV initially infects a naive mouse population, neonatal mice suffer high mortality, particularly with enterotropic MHV strains (13,14). Persistent infection with mouse hepatitis virus of low virulence in nude mice Enterotropic mouse hepatitis virus infection in nude mice ./cache/cord-022324-tcltmhi7.txt ./txt/cord-022324-tcltmhi7.txt