id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-022439-8wy7rpqv	DENMAN, A.M.	Viral Etiology of Polymyositis/Dermatomyositis	2013-11-17		.txt	text/plain	10782	523	43	Thus, theories based on a viral etiology must invoke a highly un usual host response to ubiquitous agents, the existence of uncommon viruses with the abil ity to provoke the disorder, or the possibility that virus infections operate synergistically with other factors. Attempted isolation Electron-microscopic studies Viral probes Antiviral antibody titers Establishing clones from infiltrating T lymphocytes and screening their antigen specificities Exploring the antigen specificities of associated autoantibodies In vitro models of virus-infected muscle cells In vivo models of experimental polymyositis ceptually. In clinical studies, EBV transformed blood lymphocytes from both normal individuals and patients with autoimmune diseases pro duced monoclonal autoantibodies reactive with antigens in multiple organs [93] . Myocarditis and PM induced by coxsackievirus infection is mediated by immunopathologic mechanisms that may continue to dam age muscle fibers long after infectious virus and even viral antigens have been eliminated.	./cache/cord-022439-8wy7rpqv.txt	./txt/cord-022439-8wy7rpqv.txt