id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-022822-7346069t	nan	Infections, Immunity & their Effects on Asthma	2006-10-02		.txt	text/plain	3292	148	30	The mechanisms underlying the association between RSV bronchiolitis and the later development of wheezing are incompletely understood, though there is increasing evidence that impaired antiviral immunity is likely to play an important role in increasing susceptibility to virus infections early in life, as well as perhaps the later development of asthma [3] . Areas that particularly require attention include interplay between the innate and acquired immune responses in host defence; the role of viral persistence in development of wheezing illness and asthma; the roles of antigen presenting cells and other specific cell compartments such as epithelial cells, T cells, neutrophils, eosinophils and non T cell lymphocytes in host protection and disease severity. Further studies investigating the importance of different virus types in the association between lower respiratory infection in infancy and wheezing illness in asthma are required to clarify the relationships, including rhinovirus, human metapneumoviruses, coronaviruses and bocaviruses.	./cache/cord-022822-7346069t.txt	./txt/cord-022822-7346069t.txt