id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-023740-g84fa45m	Oldstone, Michael B.A.	Mimicry by Virus of Host Molecules: Implications for Autoimmune Disease	2014-06-27		.txt	text/plain	2498	117	41	Monoclonal antibodies against 11 different viruses including DNA and RNA viruses known to cause human infection from the herpes virus group, vaccinia virus, myxoviruses, paramyxoviruses, arenaviruses, flaviviruses, alphaviruses, rhabdovirus, and coronaviruses cross-react with host cell determinants expressed on uninfected tissues. other examples (reviewed in Oldstone and Notkins, 1986 ) suggest a mechanism whereby immune reactants directed against a viral or microbial component may cross-react with a host component and generate autoimmune disease. Since, on the basis of antibody cross-reactivity, many viruses share antigenic sites with normal host cell components, the next step was to look for crossreactive capability in eliciting autoimmunity and related disease. The most likely mechanism by which molecular mimicry would cause disease is by eliciting an immune response against a determinant shared between the host and the virus to bring forth a tissue-specific immune response, presumably capable of destroying cells and eventually the tissue.	./cache/cord-023740-g84fa45m.txt	./txt/cord-023740-g84fa45m.txt