id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-023831-93xqrblk	Rosenberg, Helene F.	Pneumonia Virus of Mice (PVM): Exploring Novel Therapeutic Options In a Severe Respiratory Disease Model	2010-03-30		.txt	text/plain	3599	160	35	Our laboratories have pioneered the use of the PVM model for the study of human clinical disease, which has provided important insights into the role of the inflammatory response in the pathogenesis of severe respiratory virus infection. Our laboratories have pioneered the use of the PVM model for the study of human clinical disease, which has provided important insights into the role of the inflammatory response in the pathogenesis of severe respiratory virus infection. With these factors in mind, around 1997, we began our collaborative exploration of the pneumonia virus of mice (PVM) pathogen for the study of respiratory virus replication and the ensuing inflammatory response within a natural, evolutionarily relevant host-pathogen relationship. In a study performed using young adult (eight-12 weeks) through aged (up to 78 weeks), but otherwise immunologically naïve mice, we observed no change in the kinetics of PVM replication, but diminished local production of several proinflammatory mediators, including MIP-1a, MCP-1, and IFN-g, along with diminished recruitment of granulocytes to the lung tissue [35] .	./cache/cord-023831-93xqrblk.txt	./txt/cord-023831-93xqrblk.txt