id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-025704-icedihm2	Pawestri, Hana A.	Genetic and antigenic characterization of influenza A/H5N1 viruses isolated from patients in Indonesia, 2008–2015	2020-06-01		.txt	text/plain	6529	323	43	Since the initial detection in 2003, Indonesia has reported 200 human cases of highly pathogenic avian influenza H5N1 (HPAI H5N1), associated with an exceptionally high case fatality rate (84%) compared to other geographical regions affected by other genetic clades of the virus. Sequencing data contain valuable information about viral genetic characteristics, including presence of known human adaptive markers, resistance against available antiviral drugs or other changes that can explain the high and rising mortality, while antigenic characterization will help assess the potential protection of pre-pandemic vaccines. Amino acid sequences were analyzed to identify substitutions potentially linked to human adaptation, virulence, antiviral resistance and antigenic properties as listed in the CDC H5N1 Genetic Change Inventory [37] . Although some genetic diversity was observed in the polymerase genes, well-known substitutions such as PB2-E627K and PB2-D701N, which are often selected upon infection of humans and affects the virulence of avian influenza viruses such as H5N1 [12, 66, 67, 79] , were not commonly found in the new samples.	./cache/cord-025704-icedihm2.txt	./txt/cord-025704-icedihm2.txt