id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-026641-eemp6b5j	Kabiljo, Julijan	From threat to cure: understanding of virus-induced cell death leads to highly immunogenic oncolytic influenza viruses	2020-06-11		.txt	text/plain	6689	373	37	In the absence of NS1 apoptosis appears to be induced through the viral-RNA-mediated induction of retinoic acidinducible gene I (RIG-I) and interferon (IFN) signaling including protein kinase R (PKR) and eukaryotic initiation factor 2 alpha (eIF2α) activation and subsequent block of translation [39] [40] [41] . Another study screened a variety of wild-type influenza A viruses for their infectivity in pancreatic carcinoma cell lines and showed oncolytic effectiveness in a mouse model of human pancreatic cancer 67 . expressed a recombinant humanized cytotoxic T-lymphocyte-associated protein 4 (CTLA4) immune checkpoint inhibiting antibody from two different RNA fragments of the influenza A virus genome in order to enhance its anti-cancer effectiveness in a murine B16 melanoma model 96 . Further effects of oncolytic influenza A viruses on the cancer-immune microenvironment shown in murine models include activation of NK-cells and macrophage polarization towards immuno-stimulatory M1 phenotypes 66, 114 .	./cache/cord-026641-eemp6b5j.txt	./txt/cord-026641-eemp6b5j.txt