id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-035015-slgywe0c	Nunn, Alistair V. W.	SARS-CoV-2 and mitochondrial health: implications of lifestyle and ageing	2020-11-09		.txt	text/plain	14660	715	36	Data is now showing that COVID-19 patients do have populations of T-cells displaying mitochondrial dysfunction, as well as altered mitochondrial markers in monocyteshinting that immune-metabolic phenotyping could be used to understand disease pathogenesis and possible treatments; this could include targeting mitochondria [32] . The underlying aetiology for "inflammaging" has long thought to be associated with mitochondrial dysfunction as suggested by Nick Lane in 2003 in his "double agent" theory [5] , and is now receiving renewed interest, for instance, in how decreasing mitochondrial function can reduce T-cell function and enhance immune senescence, as mitochondria are pivotal in metabolic reprogramming towards the Warburg effect [40] . Furthermore, as evidence indicates that many viruses, which most likely include SARs-CoV-2, modulate bioenergetics and redox in both the immune system and other cells they infect to enhance their own replication, they could potentially induce excessive stress in these systems if their mitochondria are already sub-optimally functional.	./cache/cord-035015-slgywe0c.txt	./txt/cord-035015-slgywe0c.txt