id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-102898-eyyd7ent	Rizvi, Vaseef A.	Translation regulation of Japanese encephalitis virus revealed by ribosome profiling	2020-07-17		.txt	text/plain	3048	159	44	Using ribosome profiling, we identify multiple mechanisms including frameshifting, tRNA dysregulation and alternate translation initiation sites that regulate viral protein synthesis. downstream polyprotein, 2) Significant modulation in levels of a distinct subset of ribosome-bound tRNAs 48 that cannot be explained by virtue of codon usage and 3) Translation from an upstream ORF (uORF) using 49 a non-canonical initiation codon in the 5 UTR region of JEV. However, these sites do not represent commonly associated Studies on RNA viruses have suggested adaptations in codon usage of viral genes to the host translation [30] . Interestingly, JEV infection appears to stimulate 251 expression from UUG start site by almost 67% suggesting viral or virus-induced host trans-regulatory factors 252 promoting uORF translation (Fig.4D) . We also identify a subset of ribosome associated 286 tRNAs whose levels are modulated globally upon JEV infection (Fig.3) .	./cache/cord-102898-eyyd7ent.txt	./txt/cord-102898-eyyd7ent.txt