id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-161674-nk0wie0w	Liu, Zhi	Implications of the virus-encoded miRNA and host miRNA in the pathogenicity of SARS-CoV-2	2020-04-10		.txt	text/plain	5137	304	54	Our results implicated that the immune response and cytoskeleton organization are two of the most notable biological processes regulated by the infection-modulated miRNAs. Impressively, we found hsa-miR-4661-3p was predicted to target the S gene of SARS-CoV-2, and a virus-encoded miRNA MR147-3p could enhance the expression of TMPRSS2 with the function of strengthening SARS-CoV-2 infection in the gut. In the gut, 54 genes were predicted to be enhanced by 34 miRNAs. The most notable target of the virus miRNA is TMPRSS2, which is reported to enhance SARS-CoV-2 infection together with ACE2 48 In the liver, the virus miRNA mainly regulates genes involved in the function of actin filament severing and regulation of cellular protein metabolic process ( Figure 3E ). There were more than human 800 genes were predicted to be regulated by these miRNA (Figure 4A) , and a notable enrichment at the immune system process was observed There were 27 SARS-CoV-2 encoded miRNA that can target the virus genome ( Figure 5A ).	./cache/cord-161674-nk0wie0w.txt	./txt/cord-161674-nk0wie0w.txt