id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-252466-usrpodjx	Yun, Nadezhda E.	Pathogenesis of Lassa Fever	2012-10-09		.txt	text/plain	5668	290	40	Apparently, failure to develop the cellular immune response that would control dissemination of LASV, which is indicated by high serum virus titers, combined with disseminated replication in tissues and absence of neutralizing antibodies, leads to the development of fatal Lassa fever [64] . Downregulation of immune responses caused by LASV infection demonstrated in vitro is also in agreement with the results of clinical observations showing that fatal outcome of Lassa fever correlates with low levels or absence of interleukin (IL) 8 and IFN inducible protein 10 (IP-10) in circulation [70] . These data indicate that T cells are essential for rapid resolution of LASV infection; however, if the host fails to control virus replication due to inadequate activation of the immune system, T lymphocytes may play a key role in Lassa fever pathogenesis.	./cache/cord-252466-usrpodjx.txt	./txt/cord-252466-usrpodjx.txt