id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-252974-pwx27kdi	Fornek, Jamie L.	Use of Functional Genomics to Understand Influenza–Host Interactions	2007-08-31		.txt	text/plain	6755	331	42	We will explore increasingly complex models for studying influenza-host interactions using functional genomics, including cell culture systems, murine models of infection, and nonhuman primates (Fig. 1) . These studies, led by John Kash, revealed that genes related to various immune cells, notably NK cells, neutrophils, macrophages, and T helper 1 (Th1) cells, were upregulated in mice infected with the fully reconstructed 1918 virus as early as 1 day postinfection. To expand upon the above study, we have also employed functional genomics to assess the effect of influenza infection on the early innate immune response in the lungs of pigtailed macaques, how genes related to this response were regulated over time, and whether gene expression signatures of infection could also be detected in the blood. Global host immune response: Pathogenesis and transcriptional profiling of type A influenza viruses expressing the hemagglutinin and neuraminidase genes from the 1918 pandemic virus	./cache/cord-252974-pwx27kdi.txt	./txt/cord-252974-pwx27kdi.txt