id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-257019-lj1yzjn0	ter MEULEN, V.	Mechanisms and Consequences of Virus Persistence in the Human Nervous System	2006-12-16		.txt	text/plain	5189	304	44	Virus penetration may result in acute encephalitis, but occasionally a persistent infection is established that leads to a fatal slowly progressing disease, subacute sclerosing panencephalitis (SSPE). However, virus expression may sometimes be rescued from this infected tissue by co-cultivation procedure^.'^ These experiments have therefore confirmed that measles virus is the etiological agent of SSPE and also indicated that virus persistence may be based on some defect in the virus maturation process that could involve some form of host effect. The case of PRP is an exception; infectious virus may be isolated directly despite a strong antibody response in both serum and CSF.M Similarly, the cell-mediated immune system does not show any specific deficien~y.*~.~' However, the site of rubella virus antigen expression has not yet been identified during this disease process. Similarly, chronic echovirus infection is associated with immune deficiency, and although inflammatory processes are observed in extraneural tissue, it seems unlikely that C N S damage is largely caused by virus-mediated cell destruction.	./cache/cord-257019-lj1yzjn0.txt	./txt/cord-257019-lj1yzjn0.txt