id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-259260-qcfgigga	Ibrahim, Ibrahim M.	GRP78: A cell's response to stress	2019-06-01		.txt	text/plain	6837	393	50	GRP78 expression is increased in cases of ER stressors like when the cell is abridged from sugar, treated with reagents that inhibit the process of protein glycosylation or disturb the intercellular calcium storage [5] . In the standard conditions of balance in the cell (homeostasis) GRP78 is bounded in an inactive form to Activating transcription factor 6 (ATF6), protein kinase RNA-like endoplasmic reticulum kinase (PERK), and Inositol-requiring enzyme 1 (IRE1) which are UPR transmembrane stress sensors. According to the ligand or the peptide that bind to CS-GRP78, it will be activated in a defined signaling pathway that affects Besides, if the cell is cancerous, CS GRP78 will induce resistance to chemotherapy. Glucose regulated protein 78 (GRP78) inhibits apoptosis and attentinutes chemosensitivity of gemcitabine in breast cancer cell via AKT/mitochondrial apoptotic pathway De-regulation of GRP stress protein expression in human breast cancer cell lines Kringle 5 of human plasminogen induces apoptosis of endothelial and tumor cells through surface-expressed glucose-regulated protein 78	./cache/cord-259260-qcfgigga.txt	./txt/cord-259260-qcfgigga.txt