id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-262776-6k7tcgfs	Burnouf, Thierry	Assessment of the viral safety of antivenoms fractionated from equine plasma	2004-09-30		.txt	text/plain	8211	417	43	Analysis of production parameters indicate that acid pH treatments and caprylic acid precipitations, which have been validated for the manufacture of some human IgG products, appear to provide the best potential for viral inactivation of antivenoms. Among those, caprylic acid and low pH treatments, both of which are commonly used also for the purification of antivenom IgG, have been shown to contribute to the viral safety of human plasma IgG products as described below. It should be kept in mind that treatment of whole plasma or crude fractions, as is the case for equine antivenoms production, may lead to lower rate and kinetics of viral inactivation, due to the high endogenous lipid content, as found in a study that evaluated the virucidal effect of sodium oleate [85] . However, a comparison with validated manufacturing processes used for human IgG clearly indicates that at least two widely used antivenom production steps, caprylic acid treatment and low-pH incubation, are likely to contribute in a robust manner to viral safety, at least against enveloped viruses.	./cache/cord-262776-6k7tcgfs.txt	./txt/cord-262776-6k7tcgfs.txt