id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-264350-4zxp3uae	Kelley, James L.	Chapter 12. Antiviral Agents	1984-12-31		.txt	text/plain	2520	167	46	The focus of this year's chapter is on agents with activity A brief update of this year's advances More comprehensive reviews dealing VIRAL RESPIRATORY DISEASE RNA viruses are the major causative factors of the various forms of acute respiratory disease .8 respiratory tract are probably the most common cause of symptomatic human infections. Ribavirin (l-~-~-ribofuranosyl-1,2,~-triazole-3-carboxamide) -This nucleoside has activity against a broad range of DNA and RNA viruses in An tissue culture and in animal model systems.2 analysis of the status of ribavirin 3) as an is still unresolved but may involve guanosine nucleotides and inhibition of inosine monophosphate dehydrogenase.Z6 In a clinical trial against influenza A, oral ribavirin failed to alter clinical signs and symptoms of the disease.2 However, it OR OR has recently been reported to have a therapeutic effect against both influenza A and influenza B virus infections when administered to patients by inhalation of small-particle aerosol through a face m a s k .	./cache/cord-264350-4zxp3uae.txt	./txt/cord-264350-4zxp3uae.txt