id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-264699-l8db5gll	Kino, Tomoshige	Virus-mediated modulation of the host endocrine signaling systems: clinical implications	2007-06-30		.txt	text/plain	4723	226	33	For example, HIV-1-encoded gp120 molecules, which are located on the surface of the viral particle and have a major role in the entry of viruses into target cells, demonstrate amino acid sequence similarity to the growth hormone-releasing hormone (GHRH) receptor of the host and suppress the activation of this receptor by GHRH. In addition to their extracellular actions, many viral molecules act inside infected cells to modulate intracellular host signaling systems, including transcriptional regulation of target genes by hormones. In agreement with these findings, one of the HIV-1 proteins, Vpr, which is a 96-amino acid virion-associated accessory protein that has multiple functions (including influencing transcriptional activity and arresting the cell cycle), increases the effects of GR stimulation by several fold, functioning as a nuclear receptor coactivator in cooperation with a host cell coactivator complex containing p300 or its homolog CREB-binding protein (CBP) [29] [30] [31] [32] .	./cache/cord-264699-l8db5gll.txt	./txt/cord-264699-l8db5gll.txt