id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-266762-z08rn959	Rouse, Barry T.	25 Host Defenses to Viruses	2019-12-31		.txt	text/plain	7272	388	45	authors: Rouse, Barry T.; Mueller, Scott N. However, broadly neutralizing antiviral antibodies have the potential to be effective therapies against many different human infections, including HIV, influenza viruses, and Ebola virus. Initiation of adaptive immunity is closely dependent on early innate mechanisms that activate antigen-presenting cells (APCs), principally subsets of DCs. APCs and lymphocytes are drawn into lymphoid tissues by chemokine and cytokine signals and are retained there for a few days to facilitate effective intercellular interactions. 19 T-cell immunity against a particular virus involves both CD4 + and CD8 + T-cell subsets that recognize peptides derived from viral antigens bound to surface MHC proteins (class II and class I, respectively) (Chapters 5, 6). Immune responses against virus-infected cells often result in tissue damage, especially if cell killing is involved or if there is extensive recruitment and activation of inflammatory cell types, such as macrophages and sometimes neutrophils.	./cache/cord-266762-z08rn959.txt	./txt/cord-266762-z08rn959.txt