id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-268593-rvxxv1dn	Wang, Mingyang	Hemagglutinin-esterase-fusion (HEF) protein of influenza C virus	2015-07-28		.txt	text/plain	10152	468	50	Influenza C virus is unique since it contains only one spike protein, the hemagglutinin-esterase-fusion glycoprotein HEF that possesses receptor binding, receptor destroying and membrane fusion activities, thus combining the functions of Hemagglutinin (HA) and Neuraminidase (NA) of influenza A and B viruses. While influenza A and B virus contain the two glycoproteins Hemagglutinin (HA) and Neuraminidase (NA) inserted into the viral membrane, influenza C virus possesses only one spike designated Hemagglutinin-Esterase-Fusion (HEF) protein which combines the functions of both HA and NA (Herrler et al., 1988a; Herrler and Klenk, 1991) . Although there is only 12% amino acid identity between HA and HEF, the overall structure of both molecules as well as folds of individual segments are quite similar, except an additional bulge, which is located at the lower part of the globular domain and contains the esterase region that is not present in HA (Fig. 3) .	./cache/cord-268593-rvxxv1dn.txt	./txt/cord-268593-rvxxv1dn.txt