id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-269126-d81z6t0a	Jayaseelan, Vijayashree Priyadharsini	Repurposing calcium channel blockers as antiviral drugs	2020-08-19		.txt	text/plain	1141	68	45	As convincing reports on calcium channel blockers mediated increase in ACE2 expression has not been documented so far, these drugs can be a safe alternative for treating CoVID patients with hypertension. Host cells are found to modulate calcium signalling in response to viral infection and the viruses in-turn harness this environment for their own survival and propagation. Interestingly, in an attempt made to identify genetic variants associated with susceptibility to neuro-invasive disease caused by West Nile virus, CASNA1H (Calcium Voltage-Gated Channel Subunit Alpha1 H) achieved a genome-wide significance implying the fact that ionchannels could be as important as other immuno-modulatory proteins controlling host response to viral infections (Long et al. Extensive research on existing calcium channel blockers intended for use as anti-hypertensives might as well aid in repurposing these drugs into the anti-viral regimen. Host calcium channels and pumps in viral infections Calcium ions directly interact with the Ebola virus fusion peptide to promote structure-function changes that enhance infection	./cache/cord-269126-d81z6t0a.txt	./txt/cord-269126-d81z6t0a.txt