id author title date pages extension mime words sentences flesch summary cache txt cord-269324-zh1a3gwh Mubareka, Samira Human Genes and Influenza 2008-01-01 .txt text/plain 1822 93 36 Specific genes responsible for the host immune response have been invoked as major determinants of the clinical course of HIV-associated disease and hepatitis B and C virus infections [2, 3] . Clinical and animal studies indicate that cytokine dysregulation is associated with acute respiratory distress syndrome and death among hosts infected with avian influenza virus (H5N1) [4 -6] . TLR4 has been implicated in the innate immune response to respiratory syncytial virus (RSV) infection, and polymorphisms in the TLR4 gene have been associated with severe bronchiolitis in RSV-infected infants, although the significance of the Asp299Gly polymorphism appears to be a matter of ongoing debate [9 -12] . All of these genes would be excellent candidates for an analysis to iden-tify determinants of severity of disease after influenza virus infection. Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease Association between mannose-binding lectin gene polymorphisms and susceptibility to severe acute respiratory syndrome coronavirus infection ./cache/cord-269324-zh1a3gwh.txt ./txt/cord-269324-zh1a3gwh.txt