id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-270772-zshjrc87	To, Kelvin Kai-Wang	Host genes and influenza pathogenesis in humans: an emerging paradigm	2015-06-14		.txt	text/plain	4110	228	35	The emergence of the pandemic influenza virus A(H1N1)pdm09 in 2009 and avian influenza virus A(H7N9) in 2013 provided unique opportunities for assessing genetic predispositions to severe disease because many patients did not have any underlying risk factor or neutralizing antibody against these agents, in contrast to seasonal influenza viruses. Integration of knowledge from genetic and phenotypic studies is essential to identify important gene targets for treatment and prevention of influenza virus infection. Specific amino acid changes in the viral proteins have been associated with increased disease severity in humans or adaptation of avian influenza viruses in humans [13] . High-throughput screening platforms have allowed researchers to systematically screen a large number of genes associated with influenza virus infection in vitro, in animals or in humans. 9 Host genetic determinants of influenza virus disease severity identified in humans. Surfactant protein A genetic variants associate with severe respiratory insufficiency in pandemic influenza A virus infection This study incorporated in vitro, animal and human data to prioritize genes for future research on genetic susceptibility to severe influenza	./cache/cord-270772-zshjrc87.txt	./txt/cord-270772-zshjrc87.txt