id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-272066-f6q6q3io	Shim, Byoung-Shik	Sublingual Delivery of Vaccines for the Induction of Mucosal Immunity	2013-06-30		.txt	text/plain	2763	114	20	These studies have successfully demonstrated the safety and efficacy of sublingual immunization in inducing antigen-specific systemic and mucosal immune responses and protection against pathogen challenges. Taken together, these studies recognized the sublingual mucosa as a potential route of vaccine delivery, which promotes the induction broadly distributed humoral and cell-mediated immune response in systemic lymphoid tissues as well as various mucosal compartments, to offer protection against pathogens that possess tropism for mucosal epithelia. In one study, a recombinant influenza virus M2 protein-based subunit vaccine containing three tandem copies of the M2e (3M2eC) was expressed in Escherichia coli, and the protective efficacy of parenteral and sublingual immunizations was compared (7) . Sublingual sHA1 immunization induced neutralizing antibody responses in the serum and in the respiratory mucosa and provided complete protection against a lethal challenge with pandemic H1N1 influenza A/CA/04/09 virus. In this report, sublingual administration of rADV-S in mice induced SARS virus-specific neutralizing antibody response in the serum and secretory IgA response in the respiratory mucosa.	./cache/cord-272066-f6q6q3io.txt	./txt/cord-272066-f6q6q3io.txt