id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-272981-8gahvdt0	Wege, Helmut	Relapsing subacute demyelinating encephalomyelitis in rats during the course of coronavirus JHM infection	1984-08-31		.txt	text/plain	3725	295	57	These results demonstrate that mutants of JHM virus can induce a relapsing demyelinating disease process, associated with a persistent infection, which possesses some similarities to chronic experimental allergic encephalomyelitis. It has been shown that an autoimmune reaction against CNS tissue can lead to 6hronic relapsing demyelination as seen in chronic experimental allergic encephalomyelitis (EAE) whereas the role of a virus infection in the induction of such a condition has not so far been directly demonstrated (McFarlin et al. After virus infection in rats inflammatory disseminating CNS lesions of marked demyelination develop accompanied by clinical signs of a subacute disease after varying incubation times. The induction of a progressive demyelinating, or relapsing demyelinating, disease process, in JHM virus-infected rats has ~me parallels to chronic EAE, an animal model based on sensitation ~8ainst CNS tissue extracts or myelin basic protein (McFarlin et al.	./cache/cord-272981-8gahvdt0.txt	./txt/cord-272981-8gahvdt0.txt