id author title date pages extension mime words sentences flesch summary cache txt cord-273777-qb0vp9gr Happel, Anna-Ursula The Vaginal Virome—Balancing Female Genital Tract Bacteriome, Mucosal Immunity, and Sexual and Reproductive Health Outcomes? 2020-07-30 .txt text/plain 6250 279 30 A range of vaginal DNA viruses infecting eukaryote cells have been identified by shotgun metagenomics of vaginal samples from generally healthy, asymptomatic women of reproductive age participating in the Human Microbiome Project (HMP) [9] , including double-stranded (ds) DNA (families Adenoviridae, Herpesviridae, Papillomaviridae and Polyomaviridae) and single-stranded (ss) DNA viruses (families Anelloviridae) ( Table 1 and Figure 1 ). Although prokaryotic-infecting viruses, from now on referred to as bacteriophages, are estimated to be amongst the most abundant living entities on Earth [24] and are thought to play an important role in shaping the bacterial microbiota and associated health outcomes in the human gut [5, [25] [26] [27] , oral cavity [28, 29] , skin [30, 31] and lungs [32] , their role in the lower reproductive tract is understudied. Observational studies have shown that the acquisition and transmission of viral sexually transmitted infections (STIs), including HSV-2, HPV and HIV, are more common in women with high diversity, nonoptimal vaginal bacterial microbiota [42] [43] [44] . ./cache/cord-273777-qb0vp9gr.txt ./txt/cord-273777-qb0vp9gr.txt