id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-275013-na6319rg	Singh, Indra P.	Innate defences against viraemia	2000-11-23		.txt	text/plain	3294	168	42	Recently, two naturally occurring nonspecific broad‐spectrum antiviral agents, University of Texas Inhibitor β (UTIβ) glycoprotein and high density lipoprotein, have been described in human serum. In this review, we emphasise the properties of broadly active antiviral molecules in human serum and explore the possibility that they can be important as natural defence mechanisms. Based on this protection and other correlations, the authors suggested a natural defensive role for this broadly antiviral inhibitor that is present widely and in high concentration in tissues and extracellular¯uid of human nervous system [25] . The mechanisms of action of these inhibitors are competitive inhibition of virus attachment to cells and neutralisation of viral infectivity by a mechanism unlike classical antibody because complement is not needed for their activity. These observations point to a relationship in vivo between the level of serum inhibitors and in¯uenza virus multiplication and thus support the notion that the narrowly active, nonspeci®c viral inhibitors can be a factor in innate resistance to speci®c viruses.	./cache/cord-275013-na6319rg.txt	./txt/cord-275013-na6319rg.txt