id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-276009-p98wjtjb	Iyer, Arun V.	Recombinant vesicular stomatitis virus-based west Nile vaccine elicits strong humoral and cellular immune responses and protects mice against lethal challenge with the virulent west Nile virus strain LSU-AR01	2009-02-05		.txt	text/plain	7538	406	45	title: Recombinant vesicular stomatitis virus-based west Nile vaccine elicits strong humoral and cellular immune responses and protects mice against lethal challenge with the virulent west Nile virus strain LSU-AR01 These results suggest that VSV-vectored vaccines administered intranasally can efficiently induce protective humoral and cellular immune responses against WNV infections. The salient features of this vaccine study are: (1) A prime-boost intranasal vaccination approach with recombinant VSVs expressing the WNV E glycoprotein produced robust CD8 + IFN␥ + T cell responses; (2) This vaccine approach produced strong neutralizing titers against the WNV; (3) Vaccinated mice were protected against lethal challenge and they were free of neuronal necrosis, while unvaccinated mice There was no statistically significant difference observed between these two groups. These results suggest that a prime-boost VSV-vectored intranasal vaccine approach induces strong humoral and cellular immune responses that protect mice against WNV-induced neuronal necrosis.	./cache/cord-276009-p98wjtjb.txt	./txt/cord-276009-p98wjtjb.txt