id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-277417-f71jwdzj	Geoghegan, Jemma L.	The phylogenomics of evolving virus virulence	2018-10-10		.txt	text/plain	10443	468	44	Our current understanding of virulence evolution is based on insights drawn from two perspectives that have developed largely independently: long-standing evolutionary theory based on limited real data examples that often lack a genomic basis, and experimental studies of virulence-determining mutations using cell culture or animal models. Such a phylogenomic approach to studying virulence evolution is timely because of the rapidity with which virus genome sequence data are now being generated, including during ongoing disease outbreaks of emerging viruses [19] [20] [21] , and because of the development of new phylogeny-based methods for studying and visualizing genomic data [22] [23] [24] . For example, the repeated evolution of the same amino acid changes following the cross-species transmission of avian influenza virus to humans strongly suggests that they directly affect host range 66 , and a similar approach has been used to elucidate the nature of the evolutionary arms race between viruses and their hosts 67, 68 .	./cache/cord-277417-f71jwdzj.txt	./txt/cord-277417-f71jwdzj.txt