id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-279691-v5kpmk0b	Hagemeijer, Marne C.	Biogenesis and Dynamics of the Coronavirus Replicative Structures	2012-11-21		.txt	text/plain	9036	483	43	Upon infection, coronaviruses extensively rearrange cellular membranes into organelle-like replicative structures that consist of double-membrane vesicles and convoluted membranes to which the nonstructural proteins involved in RNA synthesis localize. This review will summarize the current knowledge on the biogenesis of the replicative structures, the membrane anchoring of the replication-transcription complexes, and the location of viral RNA synthesis, with particular focus on the dynamics of the coronavirus replicative structures and individual replication-associated proteins. A distinctive common feature of +RNA viruses is the replication of their genomes in the cytoplasm of the host cell in association with rearranged cellular membranes that are remodeled into organelle-like membranous structures to which the viral replication-transcription complexes (RTCs) localize. The first detectable membrane rearrangements in CoV-infected cells are 200 to 350 nm organelle-like structures that have been described for both MHV [47, 62] and the SARS-CoV [5, 63] and consist of spherical vesicles containing double lipid bilayers, termed DMVs ( Figure 2 ).	./cache/cord-279691-v5kpmk0b.txt	./txt/cord-279691-v5kpmk0b.txt