id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-280130-ewqe9edq	Weber, Friedemann	Viral suppression of the interferon system	2007-01-27		.txt	text/plain	4298	224	39	In most nucleated body cells, viral infections activate transcription of the ''classic'' IFN-b gene [1] by a signaling chain which is initiated by the RNA sensors RIG-I and MDA-5, which in turn act trough the adaptor IPS-1 and the kinases TBK-1 and IKK-3 to activate the transcription factor IRF-3 (see reviews by P. Many RNA and DNA viruses therefore express proteins which bind this key molecule to avoid both IFN induction and activation of dsRNA-dependent antiviral enzymes [7, 8] . Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factor Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling Double-stranded RNA binding of influenza B virus nonstructural NS1 protein inhibits protein kinase R but is not essential to antagonize production of alpha/beta interferon	./cache/cord-280130-ewqe9edq.txt	./txt/cord-280130-ewqe9edq.txt