id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-280854-cxpgwwjd	Kumarasamy, Dhanabal	Synthesis and in vitro antiviral evaluation of 4-substituted 3,4-dihydropyrimidinones	2017-01-15		.txt	text/plain	1649	99	53	The compounds were evaluated in vitro for their antiviral activity against a broad range of DNA and RNA viruses, along with assessment for potential cytotoxicity in diverse mammalian cell lines. The compounds were evaluated in vitro for their antiviral activity against a broad range of DNA and RNA viruses, along with assessment for potential cytotoxicity in diverse mammalian cell lines. The present work was aimed to synthesize 4-substituted 3,4-dihydropyrimidin-2(1H)-ones using various aromatic and aliphatic aldehydes and evaluate their antiviral activity against a broad range of DNA and RNA viruses, along with their cytotoxicity assessment in diverse mammalian cell lines. The antiviral activities and cytotoxicity of the synthesized compounds (4a-m and 5) were determined in CPE reduction assays with a broad and diverse panel of DNA and RNA viruses and using relevant mammalian cell lines. Compound 4m was found to be a selective and potent inhibitor of Punta Toro virus (PTV), a member of the family Bunyaviridae and the genus Phlebovirus.	./cache/cord-280854-cxpgwwjd.txt	./txt/cord-280854-cxpgwwjd.txt