id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-280986-i27mge10	Mallia, Patrick	How Viral Infections Cause Exacerbation of Airway Diseases	2017-01-25		.txt	text/plain	4238	199	34	Exacerbations are associated with increased airway inflammation in patients with both asthma and COPD, but many questions remain unanswered regarding the key inflammatory cells and mediators involved. 24, 25 In the lower respiratory tract, increases in Il-6, IL-8, and the chemokine regulated on activation, normal T-cell expressed and secreted (RANTES) have been documented in the sputum of asthmatic patients after experimental rhinovirus infection, 10, 26 and IL-8 has been detected in the sputum of children with naturally occurring exacerbations. A recent study 10 in patients with naturally occurring virusassociated asthma exacerbations found increased levels of IL-10 messenger RNA in the sputum of asthmatic patients compared to virus-infected healthy subjects, but no differences in the level of RANTES or IL-8 between the two groups. Studies 38 of airway inflammation in stable patients with COPD have shown that the disease is characterized by pulmonary infiltration of macrophages, neutrophils, and CD8ϩ T lymphocytes, together with increased expression of cytokines, chemokines, and adhesion molecules.	./cache/cord-280986-i27mge10.txt	./txt/cord-280986-i27mge10.txt