id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-284523-lknyehsa	da Mata, Élida Cleyse Gomes	Antiviral activity of animal venom peptides and related compounds	2017-01-06		.txt	text/plain	7073	347	43	This review provides a panorama of peptides described from animal venoms that present antiviral activity, thereby reinforcing them as important tools for the development of new therapeutic drugs. Synthetic hybrid peptides, namely cecropin A (1-8)-magainin 2 (1-12), exhibited potent antiviral activity by a mechanism mainly based on the compound hydrophobicity and α-helical content, inhibiting the virushost cell fusion [85] (Table 2) . Other peptides from marine sponges that inhibit HIV-1 entry into host cells are: callipeltin A, isolated from sponges of the genus Callipelta, which displayed antiviral activity with a high selectivity index (29) between the virus and host cells (SI ratio 50% cytotoxic dose [CD 50 ]/ED 50 ) [109] ; celebesides A-C from Siliquariaspongia mirabilis [108] ; neamphamide A, from Neamphius huxleyi, a compound with structural similarities to callipeptins and papuamides that exhibited low toxicity to host cells and a selectivity index above 10 [110] ; and microspinosamide, isolated from Sidonops microspinosa [111] .	./cache/cord-284523-lknyehsa.txt	./txt/cord-284523-lknyehsa.txt