id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-286219-qcx5ehnh	Calistri, Arianna	The Ubiquitin-Conjugating System: Multiple Roles in Viral Replication and Infection	2014-05-06		.txt	text/plain	10182	498	41	In this review we will present several examples of the complex interplay that links viruses and the ubiquitin conjugation machinery, with a special focus on the mechanisms evolved by the human immunodeficiency virus to escape from cellular restriction factors and to exit from infected cells. Furthermore, small DNA viruses with known oncogenic activity, such as the human papillomavirus (HPV), adenoviruses and polyomaviruses, take control of the cell cycle by usurping specific cellular Ub ligase complexes to target crucial cell cycle regulators such as p53 and the protein of the retinoblastoma (pRB) for degradation [58] . In addition to this important function, which is likely required for proper trafficking and maturation of the viral envelope glycoproteins, Vpu has been more recently characterized for yet another crucial role, connected with the ability of the virus to evade a specific IFN-1 induced antiviral factor: the B cell stromal factor 2 (BST-2) or tetherin.	./cache/cord-286219-qcx5ehnh.txt	./txt/cord-286219-qcx5ehnh.txt