id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-287151-4hlvrfeh	Steinmann, J	Surrogate viruses for testing virucidal efficacy of chemical disinfectants	2004-04-30		.txt	text/plain	2911	173	43	Abstract Since important agents of viral nosocomial infections like hepatitis B and C viruses and norovirus do not replicate sufficiently in cell culture systems, disinfectants with suspected efficacy against these viruses must be evaluated by different methods. Besides molecular approaches and indirect tests, the use of surrogate viruses with similar biophysical properties and genomic structure allows the assessment of virucidal efficacy of chemical disinfectants in quantitative suspension tests. By including these viruses in inactivation experiments, valuable data from suspension tests can be derived on the virucidal efficacy of chemical disinfectants. Besides the viruses mentioned in the guidelines, there are other important pathogens such as Hepatitis B virus (HBV), Hepatitis C virus (HCV) and norovirus which cause nosocomial infections but cannot be propagated sufficiently by cell culture techniques. Inactivation of hepatitis B virus in plasma by hospital in-use chemical disinfectant assessed by a modified HepG2 cell culture	./cache/cord-287151-4hlvrfeh.txt	./txt/cord-287151-4hlvrfeh.txt