id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-287337-2ljbsia2	Ludwig, Christine	Virus-like particles—universal molecular toolboxes	2008-01-04		.txt	text/plain	5065	205	33	It is noteworthy that VLPs assembled from HPV major capsid protein L1 in yeast were capable of inducing protective immune responses against HPV subtypes 16 and 18 causing cervical cancer in humans, thus resulting in a safe, well tolerated and highly immunogenic vaccine that received approval for marketing in 2006 [13] . Since particulate antigens had been demonstrated to induce better cellular and humoral immune responses than soluble antigens, the detection that HIV-1 Pr55Gag polyprotein self-assembles into particulate spheres provided a new rationale for generating a Gag-based VLP vaccine [15, 16] . The authors demonstrated efficient expression of murine leukemia virus (MLV) Gag-Env VLPs from plasmid DNA in vitro and used these plasmo-retroVLPs to induce strong specific CTL responses towards displayed T cell epitopes, protecting mice from lethal virus challenge. [52] have formerly shown that virosome-mediated targeting of mumps virus DNA to APCs induces specific CTL responses suggesting efficient expression and presentation of the encoded mumps antigens. DNA vaccines encoding retrovirusbased virus-like particles induce efficient immune responses without adjuvant	./cache/cord-287337-2ljbsia2.txt	./txt/cord-287337-2ljbsia2.txt