id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-287851-9p0dr7rl	Fedson, David S	Confronting an influenza pandemic with inexpensive generic agents: can it be done?	2008-09-30		.txt	text/plain	4878	277	46	The investigators commented that because of the functional redundancy of many cytokines and chemokines, deleting more than one of these genes might have had a greater (presumably more adverse) eff ect on the course of disease, and concluded that mice are suitable for evaluating agents that "modulate the infl ammatory response induced by H5N1 viruses, either alone or in combination with antiviral therapy". 18 More recently, a study of acute infl uenza pneumonia showed that compared with normal mice, Toll-like receptor (TLR) 3 knockout mice had reduced levels of several proinfl ammatory cytokines and chemokines and high pulmonary virus titres, yet mortality was unexpectedly low. For reasons of global public health it is crucially important for investigators to undertake experimental studies to determine whether these or other generic agents (or several of them in combination) could be eff ective in treating H5N1 and other potentially pandemic infl uenza virus infections.	./cache/cord-287851-9p0dr7rl.txt	./txt/cord-287851-9p0dr7rl.txt