id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-288111-0ufc54kw	ter MEULEN, VOLKER	Autoimmune Reactions Against Myelin Basic Protein Induced by Corona and Measles Viruses	2006-12-17		.txt	text/plain	2851	153	37	What apparently happens is that the viruses themselves induce Ia expression on the astrocytes, enabling these cells to present the viral antigens to the lymphocytes and allowing the host to mount an effective immune response to control the infection. However, in extremely high constitutive levels of class I1 expression on astrocytes, an inappropriate or excessive presentation of self-antigens and viral antigens may develop, similar to that in autoimmune processes directed against the thyroid gland.'" This mechanism could well play a role in the JHM-and measles-virus-induced CNS disease in Lewis rats, because as recently shown by us," these hyperexpressions of Ia molecules on astrocytes after contact with gamma-interferon or viral particles are genetically regulated. JHM and measles virus infections in rats are models of a persistent viral infection of the CNS with and without demyelination, associated with a cell-mediated immune reaction to MBP.	./cache/cord-288111-0ufc54kw.txt	./txt/cord-288111-0ufc54kw.txt