id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-290540-r0d6oaez	Rottier, Peter J.M.	The molecular dynamics of feline coronaviruses	1999-09-01		.txt	text/plain	3820	200	56	Special attention is given to the genetic dynamics of the viruses as these now allow us to begin to understand the origin of the different phenotypes, in particular the genesis of virulence during persistent infection. The conclusion from these experiments is that feline coronaviruses may persist in the lower intestinal tract where the virus continues to replicate at low levels. Conceivably, the persisting virus confers to its host resistance against superinfection by the closely related feline coronaviruses, which were infecting the other cats. The idea was that'feline enteric coronaviruses' are indeed restricted in tropism, while'FIP viruses' would cross the epithelium, infect macrophages and go systemically. The result of all these studies is that generally there is no protection when an antibody response to the spike protein is induced there is rather an enhancement of the infection, with an'early death' phenomenon. Detection of feline coronavirus RNA in feces, tissues and body fluids of naturally infected cats by reverse transcriptase PCR	./cache/cord-290540-r0d6oaez.txt	./txt/cord-290540-r0d6oaez.txt